3. The burden of insufficient physical activity

Insufficient physical activity and related non-communicable diseases increase the burden on health systems. In this chapter, the Strategic Public Health Planning for Non-Communicable Diseases (SPHeP-NCDs) model is used to calculate the impact of insufficient physical activity on non-communicable diseases and their health care expenditure for the 27 EU Member States (EU27).

The OECD has developed the SPHeP-NCDs model to quantify the impact of major risk factors on population health and the economy. To calculate the burden of insufficient physical activity, the OECD SPHeP-NCDs model is run for two scenarios. The “baseline” scenario is based on current levels of insufficient physical activity. The “no insufficient physical activity” scenario reflects a hypothetical state in which everyone achieves a sufficient level of physical activity. By comparing the outputs of these two scenarios, the burden of current insufficient physical activity levels can be calculated. Note that this analysis aims to capture the total existing burden of insufficient physical activity, rather than the potential impact of reductions in physical inactivity (e.g. the target in the WHO’s Global Action Plan on Physical Activity 2018-30 to reduce physical inactivity by 10% by 2025, and 15% by 2030 (WHO, 2018[1])).

To model a “no insufficient physical activity” scenario, a cut-off value for insufficient physical activity first needs to be defined. This is based on the recently published WHO guidelines for physical activity (WHO, 2020[2]) (see Chapter 1). For adults, the general recommendation is to engage in at least 150-300 minutes of moderate-intensity aerobic physical activity; or at least 75-150 minutes of vigorous-intensity aerobic physical activity per week, or a combination.

To be able to compare different types of physical activity, the OECD SPHeP-NCDs model measures physical activity as MET-minutes per week (see Box 3.1), using an average value of 4 METs for moderate-intensity physical activity and 8 METs for vigorous physical activity (WHO, n.d.[3]).

Following the WHO guidelines, for this report two scenarios of “no insufficient physical activity” are modelled:

  • Scenario 1: “150 minutes per week” In this hypothetical scenario, everyone in the population meets the minimum recommendation of 150 minutes of moderate-intensity1 exercise per week (equivalent of 600 MET-minutes per week). Technically, this means that in the model the physical activity levels of people doing less than 600 MET-minutes per week are increased to 600 MET-minutes per week. For people who already do more than 600 MET-minutes per week, their level of physical activity remains unchanged.

  • Scenario 2: “300 minutes per week” As the WHO guidelines indicate, higher levels of physical activity provide additional health benefits (WHO, 2020[2]). The upper limit of the recommendations is to do twice as much (i.e. more than 300 minutes of moderate-intensity activity per week), and the cut-off value can therefore be set at 1 200 MET-minutes per week. Again, technically this means that everyone doing less than 1 200 MET-minutes per week sees their physical activity level increased to this level. For people who already do more than 1 200 MET-minutes per week, their level of physical activity remains unchanged.

The choice was made to present two scenarios because 150 minutes of moderate intensity exercise, or 600 MET-minutes per week, is a commonly used cut-off value for insufficient physical activity in the literature (see Box 3.2). However, it is a conservative scenario, where only the bare minimum recommendations are met. By also including the 300 minutes (1 200 MET-minutes per week) scenario the greater potential of physical activity can be explored.

For information on the OECD SPHeP-NCDs model, and how it is used to model insufficient physical activity, please see Box 3.3, as well as the online technical documentation available at: http://oecdpublichealthexplorer.org/ncd-doc.

If everyone in the 27 countries would do at least 150 minutes of moderate-intensity exercise per week, 10 331 premature deaths (defined as deaths of people aged 30 to 70 years) would be avoided every year. This is similar to the number of deaths due to COVID-19 in that same age group in France and Germany combined in 2020. The five countries with the largest burden (Germany, France, Italy, Spain and Poland) make up three-fifths (62%) of the total burden across the 27 countries (Figure 3.2). While these are all countries with large populations, some smaller countries like Belgium and the Czech Republic also make up a considerable share of the total premature mortality burden. If the higher recommendations of 300 minutes of physical activity per week were met by everyone, nearly 30 000 premature deaths could be avoided per year.

The premature mortality rate due to insufficient physical activity is the lowest in Northern European countries, where between 2022 and 2050 less than 2 people per 100 000 inhabitants will die prematurely every year due to the effects of insufficient physical activity (less than 150 minutes per week) (Figure 3.3). The premature mortality rate is considerably higher in Romania and Lithuania, where for every 100 000 inhabitants more than 5 people will die prematurely due to insufficient physical activity. On average in the 27 EU Member States, doing 150 minutes of moderate intensity physical activity per week would prevent 2.6 premature deaths per 100 000 inhabitants – and doing at least 300 minutes per week would prevent an additional 4.8 premature deaths per 100 000 inhabitants.

If people who currently do less than 150 minutes of physical activity per week were to increase their physical activity to this target, their life expectancy would increase by 7.5 months (Figure 3.4). Their healthy life expectancy, which takes into account years lived with diseases (Box 3.4), would increase by 7.9 months. If everyone who is now doing less than 300 minutes of physical activity per week would increase their activity to this level, their life expectancy would increase by more than a year (15.7 months).

At a population level, insufficient physical activity reduces the average life expectancy in the 27 EU Member States by 1.9 months (Figure 3.5). When assuming a higher cut-off of 300 minutes, insufficient physical activity reduces life expectancy by 5.1 months. In other words, if everyone in the 27 countries would do at least 300 minutes of moderate-intensity physical activity per week, the average life expectancy of the total population would increase by nearly half a year. In comparison, EU Member States saw an average increase in life expectancy of 2.4 months per year between 2005 and 2018, due to advancements in health care, improvements in working and living conditions, healthier lifestyles and other factors (OECD/European Union, 2020[10]).

Countries with a high level of insufficient physical activity generally see a large impact on the average life expectancy of the population. On the other hand, countries such as Finland or the Netherlands have a lower level of insufficient physical activity, and the impact on the average life expectancy of the total population is therefore small.

In the 27 countries, doing less than 150 minutes of moderate-intensity exercise per week is linked to 3.5 million new cases of depression between 2022 and 2050, as well as 3.8 million new cases of cardiovascular disease, nearly 1 million new cases of type 2 diabetes and over 400 000 new cancers (Figure 3.6). Across the 12 diseases affected by physical activity in the model, doing at least 150 minutes of physical activity could prevent 11.5 million new NCDs over the next 29 years. Meeting the target of 300 minutes of physical activity per week would prevent a further 16 million cases.

The majority of disease cases due to insufficient physical activity affect people between the age of 50 and 79 years (Figure 3.7). Cardiovascular diseases account for 40% of all diseases due to insufficient physical activity in people aged 60 to 79 years, and nearly three-fourths of the burden for people over 80 years old. While cancers and cardiovascular diseases are rarer in the younger age groups, insufficient physical activity does cause a considerable burden of depression and back pain in this population. Notably, in the over-80 age group there is a decrease in back pain issues due to insufficient physical activity. This is likely the result of the decrease in life expectancy associated with insufficient physical activity, which reduces the number of people in this age group and consequently the number of diseases they develop.

If everyone were to meet the minimum physical activity guidelines of at least 150 minutes of moderate-intensity physical activity per week, 3.9% of all new type 2 diabetes cases would be avoided between 2022 and 2050, as well as 2.3% of cardiovascular disease cases. Meeting the upper guidelines of 300 minutes of physical activity per week would prevent nearly 10% of new diabetes cases, 5.2% of new cardiovascular disease cases, and around 4% of new cancer cases.

If everyone were to do at least 150 minutes of physical activity per week, a total of EUR PPP2 7.7 billion per year could be saved in health care expenditure across the 27 countries (Figure 3.8) – more than the total annual health care expenditure of Lithuania and Luxembourg combined. A large part of the burden is in countries with large populations and high health care expenditure levels, such as Germany, Italy and France.

Countries with higher health care expenditures in general tend to spend more on treating diseases linked to insufficient physical activity, and vice versa (Figure 3.9). However, the prevalence of insufficient physical activity also plays an important role: while per capita health care expenditure in Malta, Portugal and Italy is around the EU average, the high prevalence of insufficient physical activity in these countries means that the associated health care expenditure is higher than the average. The 27 countries included in the analysis could save on average EUR PPP 14.4 per capita per year between 2022 and 2050 if everyone met at least the minimum physical activity guidelines of 150 minutes of exercise per week. Meeting the guidelines of 300 minutes per week would save another EUR PPP 17.7 per capita, for a total of EUR PPP 32.2 per capita, per year.

EU Member States could save on average 0.6% of their health care expenditure if everyone did at least 150 minutes of physical activity per week (Figure 3.10). If everyone were to meet the 300 minutes guidelines, this would save 1.2% of total health care expenditure. The potential savings from doing at least 150 minutes of physical activity range from 0.16% of total health care expenditure in Estonia, to 1.2% in Malta.

References

[8] Cerin, E. et al. (2016), “Correlates of Agreement between Accelerometry and Self-reported Physical Activity”, Medicine & Science in Sports & Exercise, Vol. 48/6, pp. 1075-1084, https://doi.org/10.1249/mss.0000000000000870.

[4] Ding, D. et al. (2017), The economic burden of physical inactivity: A systematic review and critical appraisal, BMJ Publishing Group, https://doi.org/10.1136/bjsports-2016-097385.

[9] Dyrstad, S. et al. (2014), “Comparison of Self-reported versus Accelerometer-Measured Physical Activity”, Medicine & Science in Sports & Exercise, Vol. 46/1, pp. 99-106, https://doi.org/10.1249/mss.0b013e3182a0595f.

[13] Hall KD, S. (2011), “Quantification of the effect of energy imbalance on bodyweight”, Lancet, Vol. 378/9793, pp. 826-837, https://doi.org/10.1016/S0140-6736(11)60812-X.

[6] IHME (n.d.), Epi Visualization, https://vizhub.healthdata.org/epi/ (accessed on 15 October 2021).

[14] Jette, M., K. Sidney and G. Blumchen (1990), “Metabolic Equivalents (METS) in Exercise Testing, Exercise Prescription, and Evaluation of Functional Capacity”, Clinical Cardiology, Vol. 13, pp. 555-565.

[7] Lee, I. et al. (2012), “Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy”, The Lancet, Vol. 380/9838, pp. 219-229, https://doi.org/10.1016/s0140-6736(12)61031-9.

[5] OECD (2019), SPHeP-NCDs Technical Documentation, OECD, Paris, http://oecdpublichealthexplorer.org/ncd-doc.

[15] OECD (2019), The Heavy Burden of Obesity: The Economics of Prevention, OECD Health Policy Studies, OECD Publishing, Paris, https://doi.org/10.1787/67450d67-en.

[10] OECD/European Union (2020), Health at a Glance: Europe 2020: State of Health in the EU Cycle, OECD Publishing, Paris, https://doi.org/10.1787/82129230-en.

[12] Stensel, D., J. King and A. Thackray (2016), “Role of physical activity in regulating appetite and body fat”, Nutrition Bulletin, Vol. 41/4, pp. 314-322, https://doi.org/10.1111/nbu.12234.

[11] Swift, D. et al. (2014), “The Role of Exercise and Physical Activity in Weight Loss and Maintenance”, Progress in Cardiovascular Diseases, Vol. 56/4, pp. 441-447, https://doi.org/10.1016/j.pcad.2013.09.012.

[2] WHO (2020), WHO guidelines on physical activity and sedentary behaviour, World Health Organization, https://apps.who.int/iris/handle/10665/336656.

[1] WHO (2018), Global action plan on physical activity 2018-2030, World Health Organization, https://apps.who.int/iris/handle/10665/272722.

[3] WHO (n.d.), Global Physical Activity Questionnaire (GPAQ) Analysis Guide, http://www.who.int/chp/steps/GPAQ/en/index.html (accessed on 29 January 2021).

In addition to providing protective effects for a range of diseases, increased physical activity can also contribute to modest weight loss (Swift et al., 2014[11]; Stensel, King and Thackray, 2016[12]). As this lowers a person’s body-mass index (BMI), physical activity can reduce the risk of developing diseases associated with a high BMI. To capture this effect, the OECD SPHeP-NCDs model includes a link between physical activity (PA) and BMI.

The PA/BMI link is based on the widely used energy balance model developed by Hall et al. (2011[13]). An interactive version of this model is available in the form of the Body Weight Planner on the website of the National Institute of Diabetes and Digestive and Kidney Diseases (https://www.niddk.nih.gov/bwp). By varying the inputs (age, sex, weight, height, starting level of physical activity), the Body Weight Planner was used to generate a dataset to train an algorithm for the OECD SPHeP-NCDs model.

For each data entry, calorie intake was set to remain at the baseline level. The level of physical activity was assumed to change on day one, which resulted in a change in calorie output. METs were converted to calories using the following formula (Jette, Sidney and Blumchen, 1990[14]):

MET value*3.5*body weight in kg200=calories per minute

Based on this formula, the increase in daily calorie expenditure was converted to MET-minutes per week as follows:

Calories per day*2003.5*body weight in kg*7 days=METminutes per week

The resulting change in BMI was measured after one year. At this point, roughly half of the weight loss will have taken place. Reaching a bodyweight plateau is estimated to take around 10 years (Hall KD, 2011[13]), but the simulator does not go beyond 500 days. The estimated weight loss is therefore an underestimation compared to the theoretical maximum. However, in reality it can be argued that few people would maintain the increased level of physical activity and the constant level of calorie intake consistently over 10 years.

A regression analysis was used to understand how BMI is affected by changes in physical activity, as well as by age, sex, starting BMI and starting level of physical activity. Age, sex and starting BMI were all not significant, nor was an interaction term between age and changes in physical activity. This is consistent with the fact that the relative contribution of these variables to the change in BMI was also small. The interaction effect between sex and changes in physical activity was significant, as were starting physical activity level, changes in physical activity and the square function of the change in physical activity. The final algorithm used in the model is therefore:

BMI= -0.0001 046*PA+0.0000 000 204*PA2+

0.00000 313*sex*PA+ 0.0174 877*PAstart-0.0245613.

With

BMI=change in BMI in percentage

PA=change in physical activity in METs/week

sex=1, male(2,female)

PAstart=starting level of physical activity (as per below)

The level of physical activity in the Body Weight Planner is indicated by a number between 1.4 and 2.5, with a value of 1.4 representing a sedentary person. Using the “estimate your level” function in the Planner, the levels were approximately matched to the categories in the OECD SPHeP-NCDs model as follows:

Based on the algorithm, an inactive, healthy-weight man who starts to do moderate-intensity exercise twice a week for 30 minutes (delta MET minutes per week = 240) can expect to lose 1.5 kg after one year (assuming his calorie intake and non-exercise physical activity stay the same). If an overweight woman with a low level of physical activity starts to do vigorous-intensity exercise for 30 minutes, three times per week, she would lose just under 5 kg after one year.

It is important to note that the PA/BMI link in the OECD SPHeP-NCDs model is a hypothetical link to estimate the theoretical burden of disease. In this scenario, all insufficient physical activity is artificially eliminated and this increase in physical activity is linked to a change in BMI for all affected individuals. In reality however, people might not lose weight as they may increase their calorie intake or subconsciously reduce their energy expenditure in unstructured physical activity (Stensel, King and Thackray, 2016[12]).

The results presented in the main report consider the direct impact of insufficient physical activity on health, as well as the impact of insufficient physical activity on BMI and its subsequent impact on health. As high BMI is an important risk factor for a number of diseases, this link results in a substantial increase in the burden of disease. Alternatively, it is possible to model only the direct impact of insufficient physical activity on health.

One of the reasons not to include a link between physical activity and BMI is that this makes the results directly comparable to previous OECD work on the burden of obesity (OECD, 2019[15]), as both would consider only one risk factor and its consequences. However, it has to be noted that this is more of an academic exercise. In reality, insufficient physical activity does have an impact on BMI, and this adds to the burden on health and the economy. For policy makers who want to understand the impact of insufficient physical activity, and promote policies to increase activity levels, it is important to have a picture of the full extent of the issue.

Below are the results of the OECD SPHeP-NCDs model on the burden of insufficient physical activity, without the link between physical activity and BMI (PA/BMI link).

When only considering the direct impact of insufficient physical activity on premature mortality, 0.9 deaths can be avoided per 100 000 inhabitants by meeting the guidelines of 150 minutes of physical activity per week (Annex Figure 3.B.1). The additional effect of meeting the higher guidelines of 300 minutes per week is only 0.2 deaths per 100 000 inhabitants more. This is because the largest relative risks of developing disease are associated with doing less than 150 minutes per week. Including the PA/BMI link increases the impact of the 150 minutes scenario nearly three-fold (from 0.9 per 100 000 to 2.6 per 100 000).

Average life expectancy in the 27 countries decreases by 0.7 months due to the effects of insufficient physical activity, when not including the link between physical activity and BMI (Annex Figure 3.B.2). Again, the additional benefit of doing 300 minutes per week versus 150 minutes per week is small – adding only 0.1 months of life expectancy. The impact with the PA/BMI link is more than twice as large, at 1.9 months for the 150 minutes scenario. The ranking of the countries from low to high impact does not change much with the exclusion of the PA/BMI link.

When looking only at the direct effects of insufficient physical activity on health care expenditure, meeting the guidelines of 150 minutes per week would save on average EUR PPP 8.5 per capita per year across the 27 EU Member States (Annex Figure 3.B.1). This is about 40% lower than when the effect of physical activity on BMI is included, in which case the impact is EUR PPP 14.4 per capita per year. Again, there is not much change in the specific countries with relatively high and low impacts.

EU Member States could save 0.3% of their health care expenditure if everyone did at least 150 minutes of physical activity per week – when looking only at the direct impact of physical activity (Annex Figure 3.B.4). This is again about 40% lower than when the effect of physical activity on BMI is taken into account.

Notes

← 1. Going forward in this chapter, for readability, physical activity levels will be expressed only in minutes of moderate-intensity activity, without the vigorous intensity-equivalent. Note that 150 minutes of moderate-intensity exercise and 75 minutes of vigorous exercise (the lower bound recommendations) both translate into 600 MET-minutes; and 300 minutes of moderate exercise and 150 minutes of vigorous exercise (the higher bound recommendations) both translate into 1 200 MET-minutes.

← 2. Purchasing power parities (PPPs) are the rates of currency conversion that try to equalise the purchasing power of different currencies, by eliminating the differences in price levels between countries.

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