Glossary
Change in the morphology, physiology, growth, development, reproduction or life span of an organism, system or (sub) population that results in an impairment of functional capacity, an impairment of the capacity to compensate for additional stress or an increase in susceptibility to other influences (OECD, 2019[1]).
Bioassays or effect-based methods “are bioanalytical methods using the response of whole organisms (in vivo) or cellular bioassays (in vitro) to detect and quantify the effects of groups of chemicals on toxicological endpoints of concern. (Brack et al., 2019[3]) See also: in vivo tests and in vitro tests
A vast array of contaminants that have only recently appeared in water, or that are of recent concern because they have been detected at concentrations significantly higher than expected, and/or their risk to human and environmental health may not be fully understood. Examples include pharmaceuticals, industrial and household chemicals, personal care products, pesticides, manufactured nanomaterials, microplastics, and their transformation products. Also commonly known as micropollutants or emerging pollutants.
“An [endocrine disrupter] is an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations.” And, “a potential [endocrine disrupter] is an exogenous substance or mixture that possesses properties that might be expected to lead to endocrine disruption in an intact organism, or its progeny, or (sub)populations” (IPCS, 2002[7]). Also known as endocrine disrupting chemical or endocrine disrupting substance.
“A tool for identifying predominant toxicants in complex, mostly environmental mixtures combining effect testing, fractionation and chemical analysis”; “Designed to direct chemical analysis toward those chemicals that actually cause hazards mostly indicated by laboratory in vitro and in vivo bioassays” (Brack, 2011[11])
Adverse effects of chemicals that exhibit greater or even opposite effects at low doses compared to those observed at high doses. This means that traditional toxicology, which hinges on the premise that high-dose toxicity testing will proportionally inform us about low-dose exposures, does not hold (Vandenberg et al., 2012[16]).
Former wastewater that has been treated to remove solids and certain impurities. It is only intended to be used for non-potable uses (e.g. irrigation, dust control, fire suppression); with more advanced treatment, it can be used for indirect potable reuse (i.e. discharged into a water body before being used in the potable water system). Also known as reclaimed water (OECD, 2009[17]).
References
[11] Brack, W. (ed.) (2011), Effect-Directed Analysis of Complex Environmental Contamination, Springer Berlin Heidelberg, Berlin, Heidelberg, https://doi.org/10.1007/978-3-642-18384-3.
[3] Brack, W. et al. (2019), “Effect-based methods are key. The European Collaborative Project SOLUTIONS recommends integrating effect-based methods for diagnosis and monitoring of water quality”, Environmental Sciences Europe, Vol. 31/1, https://doi.org/10.1186/s12302-019-0192-2.
[10] Brack, W. et al. (2019), “Effect-based methods are key. The European Collaborative Project SOLUTIONS recommends integrating effect-based methods for diagnosis and monitoring of water quality”, Environmental Sciences Europe, Vol. 31/1, https://doi.org/10.1186/s12302-019-0192-2.
[6] EFSA (2013), “Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment”, EFSA Journal, Vol. 11/3, https://doi.org/10.2903/j.efsa.2013.3132.
[14] Fleeger, J. (2020), “How Do Indirect Effects of Contaminants Inform Ecotoxicology? A Review”, Processes, Vol. 8/12, p. 1659, https://doi.org/10.3390/pr8121659.
[7] IPCS (2002), Global Assessment of the state-of-the-science of Endocrine Disruptors, International Programme on Chemical Safety, Geneva.
[8] Jacsó, P. (2002), McGraw Hill dictionary of scientific and technical terms, https://doi.org/10.5860/choice.40-3762.
[1] OECD (2019), Pharmaceutical Residues in Freshwater: Hazards and Policy Responses, OECD Studies on Water, OECD Publishing, Paris, https://doi.org/10.1787/c936f42d-en.
[15] OECD (2018), Guidance Document on Good In Vitro Method Practices (GIVIMP), OECD Series on Testing and Assessment, No. 286, OECD Publishing, Paris, https://doi.org/10.1787/9789264304796-en.
[5] OECD (2018), Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption, OECD Series on Testing and Assessment, No. 150, OECD Publishing, Paris, https://doi.org/10.1787/9789264304741-en.
[9] OECD (2011), Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138 ENV/JM/MONO(2011)8.
[17] OECD (2009), Alternative Ways of Providing Water. Emerging Options and Their Policy Implications.
[2] OECD (n.d.), OECD Series on Adverse Outcome Pathways, OECD Publishing, Paris, https://doi.org/10.1787/2415170X.
[12] UNEP (2019), UNEP Guidance on Risk Reduction Tools for Chemicals Control, United Nations Environment Programme, Nairobi.
[13] UNEP WHO (2013), State of the Science of Endocrine Disrupting Chemicals 2012: Summary for Decision-Makers, United Nations Environment Programme and the World Health Organization.
[18] United Nations (1997), Glossary of Environment Statistics, Studies in Methods, Series F, No. 67, United Nations, New York.
[16] Vandenberg, L. et al. (2012), “Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses”, Endocrine Reviews, Vol. 33/3, pp. 378-455, https://doi.org/10.1210/er.2011-1050.
[4] Villeneuve, D. and N. Garcia-Reyero (2010), “Vision & strategy: Predictive ecotoxicology in the 21st century”, Environmental Toxicology and Chemistry, Vol. 30/1, pp. 1-8, https://doi.org/10.1002/etc.396.